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KMID : 1005220160310010097
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Journal of Embryo Transfer
2016 Volume.31 No. 1 p.97 ~ p.107
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The Need for the Development of Pig Brain Tumor Disease Model using Genetic Engineering Techniques
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Hwang Seon-Ung
Hyun Sang-Hwan
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Abstract
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Although many diseases could be treated by the development of modern medicine, there are some incurable diseases including brain cancer, Alzheimer disease, etc. To study human brain cancer, various animal models were reported. Among these animal models, mouse models are valuable tools for understanding brain cancer characteristics. In spite of many mouse brain cancer models, it has been difficult to find a new target molecule for the treatment of brain cancer. One of the reasons is absence of large animal model which makes conducting preclinical trials. In this article, we review a recent study of molecular characteristics of human brain cancer, their genetic mutation and comparative analysis of the mouse brain cancer model. Finally, we suggest the need for development of large animal models using somatic cell nuclear transfer in translational research.
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KEYWORD
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porcine , SCNT , disease-model animal , brain tumor
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